Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
INTRODUCTION: Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism.This study was designed to elucidate the cellular and molecular basis of histone-induced lethality a